atra77

2024-05-14


Streamline saloon. Another production from the Central European design school, and a remarkable one at that. Ledwinka's car had V8 engine living over the back axle, driving forward to the back axle, the whole pack easily removable. All suspension was independent and mounted in a box-section frame, with fuel tank and luggage compartment mounted centrally.

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Despite the relatively small 2.97-liter V8 mill, the T77 provided plenty of power. It was capable of 59 hp and allowed the Tatra to achieve speeds of over 90 mph (145 kph), which was an impressive ...

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This review discusses the structures, pharmacological activities, and relevant clinical trials of ATRA and its 68 analogues. • Two isomers of ATRA are introduced in detail, and the crystal structure of 9-cis-RA binding to RXRα is fully described.In APL treatment, ATRA restores transcriptional activity to ensure normal differentiation by inducing PML-RARα fusion gene.

All-Trans Retinoic Acid (ATRA) is the most active metabolite of vitamin A. It is critically involved in the regulation of multiple processes, such as cell differentiation and apoptosis, by activating specific genomic pathways or by influencing key signaling proteins. Furthermore, mounting evidence highlights the anti-tumor activity of this compound. Notably, oral administration of ATRA is the ...

The aim of this randomized clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with non-intensive chemotherapy in older unfit patients (> 60 years) with ...

Background. Acute myeloid leukaemia (AML) is the most common acute leukaemia affecting adults. Most patients diagnosed with AML are at advanced age and present with co‐morbidities, so that intensive therapy such as stem cell transplantation (SCT) is impossible to provide or is accompanied by high risks for serious adverse events and treatment‐related mortality.

Retinoic acid (RA), also known as all-trans retinoic acid (ATRA), is an important metabolite of vitamin A that mediates the functions of vitamin A required for growth and development, which is mainly attributed to gene transcription induced by ATRA [1].Vitamin A, which exhibits high biological efficacy, as has been known for nearly a century, is an extremely important fat-soluble vitamin that ...

The Tatra 77 homage pays tribute to the Czechoslovakian automobile that paved the way for the curvilinear cars we see today. Widely regarded as the world's first serial-produced, truly aerodynamically-designed automobile, the Tatra 77 was designed in 1934 by Hans Ledwinka (an Austrian automotive designer) and Paul Jaray (an aerodynamics specialist and zeppelin designer).

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